Neuronal tryptophan hydroxylase expression in human dorsal raphe nucleus neurons
نویسندگان
چکیده
منابع مشابه
Serotonin neurons in the dorsal raphe nucleus encode reward signals.
The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours; however, it remains unclear how genetically defined neurons in the DRN of a freely behaving animal respond to various natural rewards. Here we addressed this question using fibre photometry and single-unit recording from serotonin (5-HT) neurons and GABA neurons in the DRN of behaving mice. Rewards including suc...
متن کاملTryptophan hydroxylase activity in rat brain base arteries related to innervation originating from the dorsal raphe nucleus.
BACKGROUND AND PURPOSE Tryptophan hydroxylase activity was assayed in cell-free extracts of rat brain base arteries as marker of a serotonergic innervation. METHODS Estimation of the enzymatic activity was made in untreated male Sprague-Dawley rats (n = 53) and in those who underwent destruction of the dorsal and median raphe nuclei (n = 10). RESULTS Tryptophan hydroxylase activity was meas...
متن کاملEffects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.
Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induce...
متن کاملReward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus.
The dopamine system has been thought to play a central role in guiding behavior based on rewards. Recent pharmacological studies suggest that another monoamine neurotransmitter, serotonin, is also involved in reward processing. To elucidate the functional relationship between serotonin neurons and dopamine neurons, we performed single-unit recording in the dorsal raphe nucleus (DRN), a major so...
متن کاملOrexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus.
Seasonal affective disorder (SAD), a major depressive disorder recurring in the fall and winter, is caused by the reduction of light in the environment, and its depressive symptoms can be alleviated by bright light therapy. Both circadian and monoaminergic systems have been implicated in the etiology of SAD. However, the underlying neural pathways through which light regulates mood are not well...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2008
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2008.36